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This methylation profile is already acquired within the MBL stage3 and stays relatively stable after some time. Having said that, some CLL have intratumor variability in selected locations, which can alter the expression of a number of genes and aid tumor evolution.71 Of Notice, this variability is greater in U-CLL than in M-CLL and is also associated with escalating number of subclones.seven,71
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48 These translocations may perhaps come about during the context of complex karyo forms. The commonest rearrangements include 13q14, with a number of companions, as well as IGH locus. The genes most commonly rearranged with IGH are BCL2
り当て制御を行えば，性能向上が見込めると考えられる． 理論計算とシミュレーションによる評価結果から，提案
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